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Akta PD Crossflow

This listing is for the Akta crossflow filtration system

The unit is in full working condition and is ready for immediate use

An ÄKTA Crossflow filtration system is a type of tangential flow filtration (TFF) system developed by Cytiva (formerly GE Healthcare). It's used primarily in bioprocessing and biotechnology applications to concentrate, diafilter, or clarify biological samples such as proteins, viruses, plasmids, and other biomolecule

Core Functions:

Concentration – Reducing the volume of a sample while retaining the target biomolecule.

Diafiltration (Buffer Exchange) – Removing salts or changing the buffer environment by continuously adding a new buffer while removing permeate.

Clarification – Removing particulates or cells from process fluids

Key Components:

Pump Modules: Typically peristaltic pumps that manage flow rates precisely.

Filtration Cassettes: Hollow fiber or flat sheet membranes for ultrafiltration or microfiltration.

Pressure Sensors: To monitor and control transmembrane pressure (TMP).

Conductivity/pH/UV Detectors: For in-line monitoring of the filtrate and retentate.

Automated Control Software (e.g., UNICORN software): Allows recipe-based control, data logging, and trend analysis.

Benefits:

Automation reduces operator error and variability.

Scalable design for seamless transition from lab to production.

Precise control of filtration parameters (flow rate, pressure, volume).

CIP (Clean-In-Place) capabilities for easy maintenance and compliance with GMP.

Common Applications:

Protein concentration and buffer exchange

Viral vector purification

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Plasmid DNA purification

Cell harvest and clarification